Xylosyltransferase activity in diabetes mellitus Serum xylosyltransferase activity in diabetes mellitus patients as a possible marker of reduced proteoglycan biosynthesis
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چکیده
Serum xylosyltransferase activity in diabetes mellitus patients as a possible marker of reduced proteoglycan biosynthesis Christian Götting, PhD; Joachim Kuhn, PhD; Knut Kleesiek, MD Institut für Laboratoriumsund Transfusionsmedizin, Herzund Diabeteszentrum NordrheinWestfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany; Corresponding author Christian Götting, E-mail: [email protected] Received 16 May 2008 and accepted 16 July 2008 This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in print and online at http://care.diabetesjournals.org. Diabetes Care Publish Ahead of Print, published online July 23, 2008
منابع مشابه
Serum Xylosyltransferase Activity in Diabetic Patients as a Possible Marker of Reduced Proteoglycan Biosynthesis
OBJECTIVE Proteoglycan metabolism is altered in diabetic patients. The xylosyltransferases (XTs) are the initial and rate-limiting enzymes in the biosynthesis of the glycosaminoglycan chains in proteoglycans. Here, we analyzed whether the changed proteoglycan metabolism leads to altered serum XT levels in diabetic patients. RESEARCH DESIGN AND METHODS Serum XT activity was determined in 100 d...
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OBJECTIVE Xylosyltransferase I (XT-I) is the chain-initiating enzyme in the biosynthesis of proteoglycans in basement membranes. It catalyzes the transfer of xylose to selected serine residues in the core protein. The XYLT-II gene codes for a protein highly homologous to XT-I. Proteoglycans are important components of basement membranes and are responsible for their permeability properties. Typ...
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We investigated the diagnostic significance of UDP-D-xylose : proteoglycan core protein beta-D-xylosyltransferase (EC 2.4.2.26) in different chronic joint diseases. This enzyme is located almost exclusively within chondrocytes, where it initiates the formation of chondroitin sulphate during the biosynthesis of proteoglycans and from which it is easily released after damage of articular cartilag...
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Xylosyltransferase (XT) is the chain-initiating enzyme of the biosynthesis of chondroitin sulfate. So far, XT activity has been detected by incorporation of [14C]xylose in chemically deglycosylated cartilage proteoglycan or silk fibroin. However, these acceptors allow no reliable determination in blood. We found that recombinant bikunin is an excellent acceptor for XT. The Michaelis-Menten cons...
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Background and Objective: Due to the presence of some evidence for anti-diabetic and antioxidant activity of Tribulus terrestris (TT), this study was designed to investigate the anti-nociceptive effect of TT in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. Materials and Methods: Rats were divided into control, TT-treated control, diabetic, sodium salicylate (SS)...
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تاریخ انتشار 2008